Fans have not seen Fury in action in just under three years but will step up his comeback by going toe-to-toe with relatively unknown Albanian challenger Seferi.
The likes of Anthony Joshua and Deontay Wilder could come for the Gypsy King in the future if he can put on a show this evening.
With the boxing world eagerly awaiting Fury’s return, here’s how you can catch all the action.
The fight will be shown on BT Sport 1 and BT Sport 1 HD with their coverage getting underway at 7pm with a full undercard of action.
Fury’s fight will of course be the main event and it is scheduled to start at around 10:30pm.
BT Sport customers can watch the bout via all of their digital services with users of desktop or laptop computers able to use the BT Sport app.
It’s also available on iOS and Android smartphone and tablet devices as well as other platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The fight will be repeated on BT Sport several times over the next few days.
You can also keep up to date with all the action vis Starsport’s live updates with our coverage also starting at 7pm.
Fury will carry a significant weight advantage into his comeback bout against Seferi, despite shedding eight stone to get himself back into fighting shape.
Fury weighed in at 19st 10lbs at a good-natured weigh-in yesterday, making him a full four stone and nine pounds heavier than Seferi, whom he whisked off his feet and cradled in his arms as if to labour the point.
His weight makes Fury more than two stones heavier that he was for his last fight against Wladimir Klitschko in November 2015, in which he won the world heavyweight title before his career threatened to spiral out of control.
Fury was stripped of his boxing licence as he fought a ban over a failed drugs test, while his much-publicised battle against depression contributed to a weight gain which led to doubts over his boxing future.
The 29-year-old is adamant his evident success in shaping up for a ring return will increase his popularity levels and, more importantly, serve as an inspiration for others who may be going through similar health issues.
Fury said: "I've had massive support throughout all my troubles, everybody's really been helping me and spurring me on.
"This isn't just me and my team, it's me and the whole nation. I seem to have everyone behind me and I'm coming back and fighting for them.
"I'm fighting for people who need inspiration and help - people who suffer from mental health problems as well.
"It's living proof if I can do it, then anyone can do it. To come from 27 and a half stone and to get to fighting level for Saturday night, then that is a statement, isn't it."
